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(updated june,09 2022)

Sunday:  June 12, 2022

5:15 p.m. Welcome Message and Opening Remarks (David Williams, Marc Snapper & Nicolas Blanchard)
5:30 p.m.   Program Session 1:  Program Chair:  Nicolas Blanchard, FACS French Co-Chair, Uni. of Strasbourg
Advances of Catalysis and Biocatalysis for Drug Design
5:30 – 5:55      Keynote Lecture 1 and Discussion    L.-C. Campeau
Problems You Didn’t Know You Had:  Tales from the Process Chemistry Hood 
5:55 – 6:20      Keynote Lecture 2 and Discussion    Alison Narayan
Biocatalysis and Complex Molecule Synthesis
6:30 – 6:45      Keynote Lecture 3 and Discussion     Davide Audisio
Late-Stage Carbon Isotope Labeling
6:45 – 7:10      Keynote Lecture 4 and Discussion     Sheryl Wiskur
Understanding Intermolecular Interactions that Control Isothiourea Catalysis
7:10 p.m.      Adjourn
7:15 – 9:30 p.m.      Welcome Mixer

Monday:  June 13, 2022

7:00 – 8:00 a.m. Buffet Breakfast
8:00 a.m.   Program Session 2:  Program Chair:  Thomas Bannister, Sripps Florida
Enantioselective Reactions as an Approach to Increased Specificity  
8:00 – 8:55      Plenary Lecture 1 and Discussion    Stellios Arseniyadis
Direct and Highly Enantioselective Access to Gamma-Butenolides Through an Untapped C5-Selective Allylation of Siloxyfurans:  An Expedient Entry into O-Terpenoidal Natural Products 
8:55 – 9:50 Plenary Lecture 2 and Discussion    Huw Davies
Collaborative Studies in Catalyst-Controlled Site-Selective and Enantioselective C-H Functionalization
9:50 – 10:10 a.m.     Break
10:10 – 10:35 Keynote Lecture 5 and Discussion    Erica Benedetti
Asymmetric Transfer Hydrogenation: a Highly Efficient Strategy to Access Planar Chiral
10:35 – 11:30 Plenary Lecture 3 and Discussion    Jean Suffert
The Magic of the 4-Exo-Dig Carbopalladation:  How to Produce Complexity
11:30 – 11:55      Keynote Lecture 6 and Discussion    Nicholas Magnus
Diastereoselective Pictet–Spengler Based Synthesis of a D1 Potentiator
12:00 p.m. Adjourn (Lunch in the Emeline Dining Room)

1:10 p.m.   Program Session 3:  Program Chair:  Morgan Donnard, Assoc. Professor, Univ. of Strasbourg
Creating Molecular Complexity for Increased Selectivity 
1:10 – 2:05 Plenary Lecture 4 and Discussion    Marisa Kozlwoski
Oxygen Driven Fragment Coupling for the Synthesis of Natural Products and Antibacterials
2:05 – 2:30 Keynote Lecture 7 and Discussion    Oliver Thiel
Molecular Complexity as a Driver for Innovation in Pharmaceutical Process Development
2:30 – 2:55     Keynote Lecture 8 and Discussion    Adrien Quintard
From Multi-Catalyzed Transformations to Smart Materials
3:00 p.m. Adjourn
4:45 – 6:15 p.m. Poster Session A
6:30 – 7:30 p.m.      Plated Dinner in the Emeline Dining Room

Tuesday:  June 14, 2022

7:00 – 8:00 a.m. Buffet Breakfast
8:00 a.m.   Program Session 4:  Program Chair:  Nicholas Mgnus, Eli Lilly
Natural Products as Leads for Oncology and Infectious Disease 
8:00 – 8:55      Plenary Lecture 5 and Discussion    Louis Barriault
Total Synthesis of Complex Polyoxygenated Diterpenes and Photoredox Transformations
8:55 – 9:50 Plenary Lecture 6 and Discussion    Dale Boger
Vinblastine: Synthetic and Mechanistic Studies
9:50 – 10:10 a.m.     Break
10:10 – 11:05 Plenary Lecture 7 and Discussion    David Sarlah
Methodology-Driven Synthesis of Anticancer Natural Products
11:05 – 12:00      Plenary Lecture 8 and Discussion    Erwan Poupon
From Metabolomics to Bio-inspired Total Synthesis: Examples with Polycyclic Natural Products

12:00 p.m. Adjourn for Lunch (Caravel Deli in Emeline Dining Room)
Power Lunch Roundtable: Professor Marisa Kozlowski and Dr. Cathy Evans (Relay Therapeutics) will chair this discussion of issues confronting a new generation of women and underrepresented individuals. Special seating has been reserved for those who have expressed interest in attending.

1:10 p.m.   Program Session 5:   Program Chair:  Carina Sanchez, Senior Scientist, Novartis Institutes for Biomedical Research
New Targets and Novel Approaches 
1:10 – 2:05 Plenary Lecture 9 and Discussion    Maria Duca
Targeting Non-Coding RNAs with Synthetic Small Molecules for Innovative Therapeutic Applications
2:05 – 3:00 Plenary Lecture 10 and Discussion    Boris Vauzeilles
Detecting Pathogens and Reactive Oxygen Species Using Chemical Biology
3:00 – 3:25     Keynote Lecture 9 and Discussion    Fabien Rodier
A Journey in Sanofi Route Scouting Programs – Technology and Science Driven Approach
3:25 p.m. Adjourn
4:30 – 6:30 p.m.   FACS XVIII “Tastings Event”* and Poster Session B
*A tasting of French wines and American craft cheeses. 
Wines for this tasting event have been donated without consideration for any in-kind reciprocity.  Alcohol must be served exclusively by licensed Emeline personnel.
7:00 p.m.      Dinner (Conferees will be free to partake of the varied offerings within the Charleston Historic District.)

Wednesday, June 15, 2022

7:00 – 8:00 a.m.   Buffet Breakfast
8:00 a.m.   Program Session 6:  Program Chair:  Seva Rostovtsev, Director, FMC Corporation
Advances in Heterocyclic Chemistry and Novel Pharmacophores  
8:00 – 8:25      Keynote Lecture 10 and Discussion    Alex Radosevich
Synthetic Methods Driven by the P(III)/P(V) Redox Couple
8:25 – 9:20 Plenary Lecture 11 and Discussion    Sami Lakhdar
Mechanistically Driven Development of Carbon–Carbon & Carbon–Heteroatom Bond Forming Reactions
9:20 – 10:15     Plenary Lecture 12 and Discussion    John Vederas
Synthesis of Cyclic Bioactive Peptides, Their Analogs and Unusual Amino Acid Building Blocks
10:15 – 10:30 a.m. Break
10:30 – 11:25 Plenary Lecture 13 and Discussion    Marine Desage-El Murr
Interfacing Redox Catalysis with the Metalloenzymatic Reactivity Toolbox
11:25 – 12:20      Plenary Lecture 13 and Discussion    Nicholas Meanwell
Inhibitors of HIV-1 Maturation
12:00 p.m. Adjourn for Lunch (Caravel Deli in Emeline Dining Room)

1:30 p.m.   Program Session 7:   Program Chair:  Xianglin Shi, Chief Technology Officer, Leal Therapeutics
Molecules as Sensors and Probes  
1:30 – 1:55 Keynote Lecture 11 and Discussion    Martin Schnermann
Harnessing Cyanine Chemistry for Dynamic & Multicolor Imaging
1:55 – 2:50       Plenary Lecture 15 and Discussion    Mike VanNieuwenhze
Visualization of Bacterial Cell Wall Synthesis and Cell Division with Fluorescent D-Amino Acids
2:50 – 3:15       Keynote Lecture 12 and Discussion    Kevin Meyer
Creating a New Class of Fungicides
3:20 p.m. Adjourn (Free time to explore Historic Charleston)
7:00 p.m.      Conference Banquet in Emeline Dining Room

Thursday:  June 16, 2022

7:00 – 8:00 a.m.   Buffet Breakfast
8:00 a.m.   Program Session 8:  Program Chair:  Ángel Morales-Ramos, Scientific Leader, GSK
Translation Sustainability in Process Research  
8:00 – 8:25 Keynote Lecture 13 and Discussion      Nick Desrosiers
Process Chemistry Development for the EZH2 Inhibitor PF-06821497
8:25 – 8:50     Kenote Lecture 14 and Discussion    Laurent Petit
Process Development of a Novel Route to Rilpivirine Hydrochloride – From Lab Scale to Pilot Scale
8:50 – 9:15     Kenote Lecture 15 and Discussion    Carina Sanchez
Adventures in Synthetic Innovation: A Chiral Synthesis of NVP-LNP023
9:15 – 10:25 a.m.  Break (Remove luggage from hotel rooms for checkout.)

10:30 a.m.   Program Session 9:  Program Chair:  Khalida Shamim, Therapeutics Development Branch, NCATS
New Technologies to Accelerate Drug Discovery  
10:30 – 10:55 Keynote Lecture 16 and Discussion      Amanda Dombrowski
Enabling and Accelerating Drug Discovery with High-Throughput Chemistry
10:55 – 11:50     Plemanry Lecture 16 and Discussion    Laure Haberkorn
Accelerating the Design-Make-Test-Analyse Cycle, Which Technologies to Use and for What Purpose?
12:00 – 10:30     Conference Closing and Concluding Remarks